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Hepatitis | ||||||
| Hepatitis
was traditionally separated into two types based on clinical and epidemiological
characteristics: type A caused by the hepatitis A virus (HAV) and type B
caused by the hepatitis B virus (HBV). Hepatitis C virus (HCV) cannot be
cultivated, and it was only through recombinant DNA technology that a diagnostic
test was devised to identify hepatitis C as the major cause of what had
previously been termed non-A non-B (NANB) hepatitis.
Transmission of hepatitis A is via the faecal-oral route, through contaminated food or water. Thorough cooking will destroy the virus, but shellfish, which are usually eaten raw, may become infected from sewage contaminated seawater and become a vehicle for transmission. Hepatitis B is transmitted parenterally and sexually. Transmission most commonly occurs following sexual intercourse, as a result of blood to blood contact, including injury with contaminated sharp instruments or other equipment by intravenous drug misusers, or by perinatal transmission from mother to child. Transfusion associated infection is now rare and adequate treatment of blood products has eliminated these as sources of infection in the UK. A hepatitis B vaccine is available and routine immunisation of at-risk groups is recommended. These include certain groups of health care workers, babies born to hepatitis B positive mothers and injecting drug users. Infection with hepatitis C virus is associated with intravenous drug use or blood products. Sexual, vertical and occupational transmission do occur, but on a less frequent basis than HBV. Transfusion associated infection is now rare in the UK. A vaccine for hepatitis C is not available. Other hepatitis viruses have been identified. Hepatitis D is always associated with co-infection of HBV. Hepatitis E, like HAV, is transmitted by the faecal-oral route, often associated with gross contamination of water supplies (usually by sewage). |
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Last Updated: 16/04/2007 © Copyright CDSC(NI) 2002 |
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